MONTH 4 · WEEKS 13 – 16
Jamie's March recap
Tirzepatide · 7.5 mg weekly · Titration phase
FROM ERIC
What changed this month
You moved from 5 mg to 7.5 mg in week 13 and held through the full month. Weight came down 4.2 lb against a goal pace of 3.5 — slightly ahead. Appetite scored 2/5 fewer days, side effects half what they were on the dose-up week, journal entries on day-after-shot showed the trough timing has shifted earlier (Tuesdays now, was Wednesdays at 5 mg).
This is the dose-finding window. Don't go up to 10 mg yet — there's another month of useful titration response still hiding in the 7.5 mg curve. Your fullness scores haven't plateaued.
WEIGHT
Down 4.2 lb · trend −0.96 lb/week
UNITS: LB
Your trend slope steepened from −0.71 lb/wk on 5 mg to −0.96 lb/wk after the step-up — the kind of inflection that confirms the dose change is doing useful work.
ADHERENCE
4 / 4 shots · 22 / 28 weigh-ins
- SHOTS LOGGED
- 4 of 4Sundays
- WEIGH-INS
- 22 of 2879% · skipped 3 weekends
- JOURNAL ENTRIES
- 11avg 2.75/week
- SYMPTOM LOGS
- 7all minor (nausea ≤2)
SIDE EFFECTS
Mild · resolved within 48h
Week 13 (dose-up week) showed expected breakthrough nausea on Mon + Tue — both rated 2/5, both resolved by Wednesday evening. No reports in weeks 14–16. No gallbladder symptoms, no constipation flags, no early satiety beyond expected.
Cohort+ pulls the journal text alongside the symptom score so the prescriber sees context, not just numbers. Sample entry from your Wk 13 Tuesday: “Skipped breakfast, tried plain toast at 11, kept it down. Hydration helped.”
LAB MARKERS
A1C 5.8 → 5.6 · LDL stable
- A1C
- 5.6 %down from 5.8 (Jan)
- FASTING GLUCOSE
- 94 mg/dL+0 from last quarter
- TOTAL CHOLESTEROL
- 198 mg/dL−12 from baseline
- LDL
- 108 mg/dLwithin ±5
- TRIGLYCERIDES
- 134 mg/dL−18 from baseline
- RESTING HEART RATE
- 68 bpm−4 from baseline
The A1C drop is well within the expected tirzepatide range for your starting profile. Triglycerides moving in tandem with weight is the pattern you want — confirms metabolic response, not just scale movement.
OFF-RAMP READINESS
Not yet · 6 – 9 months out
The model gives an off-ramp readiness score based on dose-response stability, weight trajectory predictability, and lab markers. Yours is currently 38 / 100 — well below the 75 threshold we treat as a starting point for a prescriber-led taper conversation.
Realistic earliest off-ramp window if you stay on 7.5 mg: ~6 months from today. If you step up to 10 mg at month 5, that pushes to ~8 months from today (the model favors longer titration runs over rushed step-downs).
FOR NEXT MONTH
Two things to watch
- Trough day timing. Your shift to Tuesday trough is normal at higher doses. If it slides further back (Monday), that's a signal the 7.5 mg dose is running out earlier than the weekly schedule — log it, we'll re-check next month.
- Resistance work. Cohort+ only sees what you log; if you started lifting this month and didn't add it to the activity tab, the model is undercounting your lean-mass preservation signal. Worth backfilling.